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Patients with renal insufficiency may be at increased risk while on such therapy. The cationically modified resin is excreted in the feces. Potassium Acetate: (Contraindicated) Sodium polystyrene sulfonate is indicated for the treatment of hyperkalemia. More hydrogen ions are lost from the stomach than are lost from the intestine, resulting in metabolic alkalosis. Once in the gastrointestinal lumen, the insoluble resin swells allowing for the sodium contained within the polymer to be exchanged for potassium and other cations dissolved within the gastrointestinal tract; this action occurs primarily in the large intestine. Calcium Carbonate; Simethicone: (Major) Simultaneous oral administration of cation-donating antacids or laxatives may reduce the potassium exchange capability of sodium polystyrene sulfonate. After administration is complete, flush the tube with an age-appropriate amount of fluid (50 to 100 mL is recommended for adults), clamp the tube, and leave in place. With appropriate monitoring, hypokalemia can be avoided. If the enema contained sorbitol, particular attention should be paid to the cleansing enema to ensure proper removal. "granfather was prescribed kayexalate (sodium polystyrene sulfonate) 60gm and then 45gm today and 45gm tomorrow. Normally, antacids like magnesium hydroxide and calcium carbonate neutralize hydrochloric acid in the stomach, forming magnesium chloride and calcium chloride. Calcium Carbonate; Risedronate: (Major) Simultaneous oral administration of cation-donating antacids or laxatives may reduce the potassium exchange capability of sodium polystyrene sulfonate. Skip to Content. Administration of all potassium salts should be discontinued whenever therapy with sodium polystyrene sulfonate is indicated. Oral suspension: 15 g/60 ml Oral powder for suspension: 454 gm Rectal suspension: 15 g/60 ml With appropriate monitoring, hypokalemia can be avoided. Do not use the medicine orally or rectally in a baby who has slow digestion caused by surgery or by using other medicines. Rectal administration of sodium polystyrene sulfonate may reduce the severity of these interactions. Administration of all potassium salts should be discontinued whenever therapy with sodium polystyrene sulfonate is indicated. Examples of cation-donating antacids and laxatives include aluminum hydroxide, calcium carbonate, magnesium carbonate, magnesium citrate, and magnesium hydroxide. In the event of clinically significant constipation, discontinue treatment with sodium polystyrene sulfonate until normal bowel motion is resumed. One case of grand mal seizure has been reported in a patient with chronic hypocalcemia of renal failure who was given sodium polystyrene with magnesium hydroxide as laxative. As these compounds enter the small intestine, they react with bicarbonate, forming magnesium carbonate and calcium carbonate, which are insoluble. More hydrogen ions are lost from the stomach than are lost from the intestine, resulting in metabolic alkalosis. In adults, up to 2 quarts of fluid may be necessary. Sodium Polystyrene Sulfonate Powder, for Suspension is indicated for the treatment of hyperkalemia. Because the resin can alter other electrolytes (e.g. Because of differences in onset of action, sodium polystyrene sulfonate is often used with these agents. In 2016, the Donut Hole begins once you’ve spent $3,310 in one year. In both children and neonates, particular care should be observed with rectal administration, as excessive dosage or inadequate dilution could result in impaction of the resin. In neonates, sodium polystyrene sulfonate should not be given by the oral route and certain products containing sorbitol are contraindicated for use in neonates by any route. In addition, sodium polystyrene sulfonate should be used with caution in patients with hypernatremia or who require sodium restriction (i.e. Specific maximum dosage information is not available. If polystyrene is administered, it blocks this reaction by binding to the magnesium and calcium ions before they can react with the bicarbonate. As these compounds enter the small intestine, they react with bicarbonate, forming magnesium carbonate and calcium carbonate, which are insoluble. The drug also reduces total body calcium and should be used with caution in patients with hypocalcemia. Administration of all potassium salts should be discontinued whenever therapy with sodium polystyrene sulfonate is indicated. For doses of 30 to 50 g, mix each dose with at least 100 mL aqueous vehicle. Breast-feeding is not expected to result in risk to the infant. Because of differences in onset of action, sodium polystyrene sulfonate is often used with these agents. To minimize the risk of impaction, use the lowest effective dose, properly dilute the powder for suspension, and after the enema is complete, adequately irrigate using a sodium-free cleansing fluid to ensure full recovery of the resin. © Copyright 2020 Healthgrades Operating Company, Inc. Patent US Nos. Normally, antacids like magnesium hydroxide and calcium carbonate neutralize hydrochloric acid in the stomach, forming magnesium chloride and calcium chloride. 2 Qualitative and Quantitative Composition. Sodium polystyrene sulfonate should only be used in patients with normal bowel function; avoid use in patients at risk for developing constipation or fecal impaction (i.e., those with a history of fecal impaction, chronic constipation, inflammatory bowel disease, ischemic colitis, previous bowel resection, or bowel obstruction). Find patient medical information for sodium polystyrene sulfonate oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Patients who received concomitant oral sodium polystyrene sulfonate and non-absorbable cation-donating antacids and laxatives have developed systemic alkalosis. Rectal administration of sodium polystyrene sulfonate may reduce the severity of these interactions. With appropriate monitoring, hypokalemia can be avoided. Insulins: (Moderate) Sodium polystyrene sulfonate should be used cautiously with other agents that can induce hypokalemia such as loop diuretics, insulins, or intravenous sodium bicarbonate. As these compounds enter the small intestine, they react with bicarbonate, forming magnesium carbonate and calcium carbonate, which are insoluble. Cation exchange resins can bind thyroxine or levothyroxine in the GI tract and inhibit oral absorption, potentially leading to hypothyroidism.. Torsemide: (Moderate) Sodium polystyrene sulfonate should be used cautiously with other agents that can induce hypokalemia such as loop diuretics, insulins, or intravenous sodium bicarbonate. If polystyrene is administered, it blocks this reaction by binding to the magnesium and calcium ions before they can react with the bicarbonate. 3 PHARMACEUTICAL FORM Sodium Polystyrene Sulfonate is indicated for the treatment of hyperkalemia. With rectal administration, the minimum effective dosage within the range of 0.5 g/kg to 1 g/kg should be given diluted as for adults and with adequate irrigation to ensure recovery of the resin. Sodium polystyrene sulfonate binds to many commonly prescribed oral medicines, decreasing the absorption and therefore the effectiveness of those oral medicines. Authors from another study suggest an initial dose of 5 mL of sodium polystyrene powder (measured as leveled powder in a medicine cup) per 770 mL formula (this dose corresponds to about 0.5 to 0.65 g per 100 mL formula, depending on the brand of sodium polystyrene sulfonate used). The drug is a cream to light brown finely ground, powdered form of sodium polystyrene sulfonate, a cation-exchange resin prepared in the sodium phase with an in vitro exchange capacity of approximately 3.1 mEq (in vivo approximately 1 mEq) of potassium per gram.The sodium content is approximately 100 mg (4.1 mEq) per gram of the drug. A dosage of 0.5 to 1 g sodium polystyrene sulfonate powder per 100 mL formula/breast milk appears to be a common initial dosage range used. Potassium Citrate: (Contraindicated) Sodium polystyrene sulfonate is indicated for the treatment of hyperkalemia. KAYEXALATE (sodium polystyrene sulfonate) is a cream or light brown fine powder of sodium polystyrene sulfonate. Omeprazole; Sodium Bicarbonate: (Moderate) Sodium polystyrene sulfonate should be used cautiously with other agents that can induce hypokalemia such as loop diuretics, insulins, or intravenous sodium bicarbonate. More hydrogen ions are lost from the stomach than are lost from the intestine, resulting in metabolic alkalosis. DOSAGE AND ADMINISTRATION. Administration of all potassium salts should be discontinued whenever therapy with sodium polystyrene sulfonate is indicated. The in vivo exchanges ratio is estimated to be approximately 1 meq of potassium for each gram of SPS administered. You should confirm the information on the PDR.net site through independent sources and seek other professional guidance in all treatment and diagnosis decisions. Aluminum Hydroxide; Magnesium Hydroxide; Simethicone: (Major) Simultaneous oral administration of cation-donating antacids or laxatives may reduce the potassium exchange capability of sodium polystyrene sulfonate. Administer sodium polystyrene sulfonate 3 hours before or 3 hours after other orally administered medications to prevent sodium polystyrene sulfonate from binding to other oral medications, which may result in decreased gastrointestinal absorption and reduced efficacy of the bound drug.

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