ravindra gupta cambridge

Institutes and Centers. Nature; 2019 Mar 5. doi: 10.1038/s41586-019-1027-4. In Spring 2020 the team validated and introduced the SAMBA II point of care test into clinical practice at Addenbrookes for rapid diagnosis of COVID-19. In press, MBio; 2020, Gupta-Wright A, Fielding K, van Oosterhout J, Alufandika M, Grint D, Chimbayo E, Heaney J; Byott M, Nastouli E; Mwandumba H, Corbett E, Gupta RK. Pfizer vaccine sera activity against B.1.1.7, Prelim Paper – Responses to SARS-CoV-2 following vaccination. Ravindra Gupta is an Indian-origin British citizen, who also holds overseas citizenship of India. So regt Ravindra Gupta von der Universität Cambridge an, schon jetzt Impfstoffe zu produzieren, die eine Immunität gegen die Mutationen verschaffen. Verified email at cam.ac.uk. This year, India’s Prime Minister Narendra Modi, Bollywood actor Ayushmann Khurrana and Professor Ravindra Gupta are among TIME’s 100 most influential people of … Home; About. Now he has mine, as well," the London Patient writes. Sort by citations Sort by year Sort by title. He is the professor of Clinical Microbiology and Wellcome Trust Senior Fellow in Clinical Science at The University of Cambridge and faculty at the Africa Health Research Institute in Durban, South Africa. Click here for a full list of publications. COVID-19: What can we learn from the HIV/Aids Pandemic? The Gupta lab has worked extensively in HIV drug resistance, both at molecular and population levels, and contributed to the appreciation of the scale of drug resistance globally. Gupta was included in Time magazine 's 100 Most Influential People in 2020. Gupta RK, Abdul-Jawad S, McCoy LE, Mok HP, Peppa D, Salgado M, Martinez-Picado J, Nijhuis M, Wensing AMJ, Lee H, Grant P, Nastouli E, Lambert J, Pace M, Salasc F, Monit C, Innes A, Muir L, Waters L, Frater J, Lever AML, Edwards SG, Gabriel IH, Olavarria E. HIV-1 remission following CCR5Δ32/Δ32 haematopoietic stem-cell transplantation. We are using cookies to give you the best experience on our website. Ravindra Gupta, a professor of clinical microbiology at the Cambridge Institute of Therapeutic Immunology and Infectious Disease. Gupta RK, Hué S, Schaller T, Verschoor E, Pillay D and Towers GJ. Ravindra Gupta aka Ravi Gupta is the professor of Clinical Microbiology and Wellcome Trust Senior Fellow in Clinical Science at The University of Cambridge and faculty at the Africa Health Research Institute in Durban, South Africa. Simian Immunodeficiency Virus envelope glycoprotein counteracts tetherin/BST-2/CD317 by intracellular sequestration. Keeping this cookie enabled helps us to improve our website. The EMBO J.; 2018; 37:50–62, Gupta RK, Gregson J, Parkin N, Haile-Selassie H, Tanuri A, Andrade Forero L, Kaleebu P , Watera C, Aghokeng A, Mutenda N, Dzangare J, Hone S, Hang ZZ, Garcia J,  Garcia Z, Marchorro P, Beteta E, Roman M, Giron A, Hamers R, InzaukeS, Frenkel LM, Chung MH,de Oliveira T, Pillay D, Naidoo K, Kharsany A, Kugathasan R, Cutino T, Hunt G, Avila Rios S, Doherty M, Jordan MR, Bertagnolio S. HIV-1 drug resistance prior to initiation or re-initiation of first-line antiretroviral therapy in low- and middle-income countries – a meta regression analysis. Year; SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes. During the latter half of 2020 the lab started to study evolution of the virus within patients in response to antibody based therapies, as a paradigm of how new variants with multiple mutations have arisen. The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for virus infection through the engagement of the … He is the professor of Clinical Microbiology and Wellcome Trust Senior Fellow in Clinical Science at The University of Cambridge and faculty at the Africa Health Research Institute in Durban, South Africa. Der weltweit erste Mensch, der nach einer HIV-Infektion geheilt werden konnte, ist an den Folgen einer Krebserkrankung gestorben. The Gupta lab has teams in both the UK and at the Africa Health Research Institute in Durban South Africa. HIV. Upon return he trained in infectious diseases in Oxford and London (UCLH, Hospital for Tropical Diseases) and completed his PhD at UCL on Lentiviral evasion of antiretrovirals and innate immune responses. "I’m so fortunate and humbled to know him, and to see how his dedication can conquer this disease," wrote Adam Castillejo in his brief about the professor in Times magazine. According to the researchers, including Ravindra Gupta from Cambridge University in the UK, the dominant variant that emerged in the patient after the plasma therapy possessed a … Ravi Gupta has been Professor of Clinical Microbiology at the Cambridge Institute for Therapeutic Immunology and Infectious Diseases since 2019. Join Facebook to connect with Ravindra Gupta and others you may know. "He was thoughtful and compassionate, and his accomplishments—now including oversight of the stem-cell treatments I received from a donor with a rare gene mutation, which led to my remission—clearly earned him respect and admiration from his colleagues in the HIV research community. Deployment of the SAMBA II rapid diagnostic testing machines in Addenbrooke's Hospital was reported here, and in a BBC interview, in April 2020. • Ravindra Gupta is professor of clinical microbiology and honorary consultant physician at Cambridge Institute for Therapeutic Immunology and Infectious Diseases, University of Cambridge… Das teilte die International Aids Society (AIS) am Mittwoch mit. The Lancet HIV; 2020; S2352-3018(20)30069-2. In press, Nature Communications 2020, Collier DA, Assennato SM, Warne B, Sithole N, Sharrocks K, Ritchie A, Ravji P, Routledge M, Sparkes D, Skittrall J, Smielewska A, Ramsey I, Goel N, Curran M, Enoch D, Tassell R, Lineham M, Vaghela D, Leong C, Mok HP, Bradley J, Smith KGC, Mendoza V, Demiris N, Besser M, Dougan G, Lehner PJ, Siedner MJ, Zhang H, Waddington CS, Lee H, Gupta RK; CITIID-NIHR COVID BioResource Collaboration. COVID-19: What can we learn from the HIV/Aids Pandemic? EMBO Journal; 2017;  e201696025. SiednerMJ, MoorhouseMA, SimmonsB, deOliveiraT, LessellsR, GiandhariJ, KempSA, ChimukangaraB, AkpomiemieG, SerenataCM, VenterWDF, HillA, Gupta RK. Ravindra Gupta is professor of clinical microbiology and honorary consultant physician at Cambridge Institute for Therapeutic Immunology and Infectious Diseases, University of Cambridge Gupta RK, Hill A, Sawyer W, Cozzi-Lepri A, von Wyl V, Yerly S, Dias Lima V, Gunthard HF, Gilks C, Pillay D. Virological monitoring and resistance to first-line highly active antiretroviral therapy in adults infected with HIV-1 treated under WHO guidelines: a systematic review and meta-analysis. DNA damage induced by topoisomerase inhibitors activates SAMHD1 and blocks HIV-1 infection of macrophages. “There’s a load of mutations that occur together at the same frequency,” he wrote on Dec. 2 to Dr. Ravindra Gupta, a Cambridge virologist. Cambridge physician and microbiologist Professor Ravindra Kumar Gupta is one of six persons of Indian-origin on the latest Time 100 Most Influential … Sort by citations Sort by year Sort by title. Dissecting the biology of macrophage-virus interactions given myeloid cells are parasitised by HIV and are a difficult-to-treat reservoir. All photographs: Kind courtesy Ravindra Kumar Gupta Ravindra Gupta led a team of doctors that enabled a second person to experience sustained remission from AIDS after ceasing treatment, according to a study published in Nature. Prof. Ravindra Gupta of Cambridge University, one of the top scientists working on the worrying new mutant strain of the coronavirus, has said: “This virus is potentially on a pathway for vaccine escape, it has taken the first couple of steps towards that.” Ravi Gupta has been Professor of Clinical Microbiology at the Cambridge Institute for Therapeutic Immunology and Infectious Diseases since 2019. Proof-of-principle for immune control of global HIV-1 reactivation in vivo. Ravindra Gupta, MD, PhD. SARS-CoV-2 evolution during treatment of chronic infection. Gupta was included in Time magazine 's 100 Most Influential People in 2020. Politicians lack the will to allocate funds for public healthcare because it is a costly and long-drawn affair and one can only hope that the COVID-19 crisis will teach them why they need an investment in science, said Professor Ravindra K Gupta, recently named in Time's list of the 100 most influential people of 2020. Smith NMG, Mlcochova P, Watters SA, Aasa-Chapman, Rabin N, Moore S, Edwards SG, Garson JA, Grant PR, Ferns RB,  Kashuba A, Mayor NP,  Schellekens J, Marsh SGE,  McMichael AJ, Perelson AS, Pillay D, Goonetilleke N, Gupta RK. Clinical Infectious Diseases. [1] [2] [3] Em 2020, apareceu na lista de 100 pessoas mais influentes do mundo do ano pela Time. Nathalie Kingston. Ravi Gupta has been Professor of Clinical Microbiology at the Cambridge Institute for Therapeutic Immunology and Infectious Diseases since 2019. In press Nature 2021. Cited by. Year; SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes. Gupta RK, Mlcochova P, Pelchen-Matthews A, Petit SJ, Mattiuzzo G, Pillay D, Takeuchi Y, Marsh M, Towers GJ. Ravindra Kumar Gupta. COVID-19 related work Published online 25.01.2017, Kugathasan R, Collier DA, Haddow LJ, El Bouzidi K, Edwards SG, Cartledge JD, Miller RF, Gupta RK. Virological Outcomes of second– line protease inhibitor based treatment for HIV– 1 in a high prevalence rural South African setting – a competing risk prospective cohort analysis. Who is Ravindra Gupta? His training includes public health and molecular virology and aims to deploy this in pursuit of transformative new knowledge. In Vivo Emergence of a Novel Protease Inhibitor Resistance Signature in HIV-1 Matrix. Our work focuses on two areas: Having completed his medical undergraduate studies at Cambridge and Oxford Universities, Ravi Gupta pursued a Masters in Public Health at Harvard as a Fulbright scholar. Dr. Ravindra Gupta, left, and Dr. Steven Kemp in the research laboratories at the Jeffrey Cheah Biomedical Centre, in Cambridge, England on Jan. 14, 2021. In June, Ravindra Gupta, a virologist at the University of Cambridge, heard about a cancer patient who had come into a local hospital the month before with COVID-19 and was still shedding virus. PLoS Pathogens; 2009 May;5(5):e1000443. Gupta-Wright A, Fielding K, van Oosterhout J, Alufandika M, Grint D, Chimbayo E, Heaney J; Byott M, Nastouli E; Mwandumba H, Corbett E. . Cambridge physician and microbiologist Professor Ravindra Kumar Gupta is one of six persons of Indian-origin on the latest Time 100 Most Influential People 2020 list.. Northwestern Medicine Doctor Profile; Institutes and Centers. Verified email at cam.ac.uk. Cited by. Lancet Infect Dis; May 2016; Volume 16, No. Cell Reports Medicine; 2020; Jul 15:100062. doi: 10.1016/j.xcrm.2020.100062, Mlcochova P, Collier D, Ritchie A, Assennato SM, Hosmillo M, Goel N, Meng B, Chatterjee K, Mendoza V, Temperton N, Kiss L, James LC, Ciazynska KA, Xiong X, Briggs JA, Nathan JA, Mescia F, Bergamaschi L, Zhang H, Barmpounakis P, Demeris N, Skells R, Lyons PA, Bradley J, Baker S, Allain JP, Smith KG, Bousfield R, Wilson M, Sparkes D, Amoroso G, Gkrania-Klotsas E, Hardwick S, Boyle A, Goodfellow I, Gupta RK; CITIID-NIHR COVID BioResource Collaboration. Ravindra Gupta is an Indian-origin British citizen, who also holds overseas citizenship of India. Ravindra Kumar Gupta. Research summary. Gupta Group. In March 2019, Gupta led a team demonstrating HIV remission in an HIV positive man with advanced Hodgkin's lymphoma following an 'unrelated' stem cell transplant. Professor Ravindra "Ravi" Kumar Gupta is a professor of clinical microbiology at the Cambridge Institute of Therapeutic Immunology and Infectious Disease at th… Reduced efficacy of HIV-1 integrase inhibitors in patients with drug resistance mutations in reverse transcriptase. Virological failure, HIV-1 drug resistance and early mortality in adults admitted to hospital in Malawi: a nested observational cohort study. Ravindra Gupta aka Ravi Gupta is the professor of Clinical Microbiology and Wellcome Trust Senior Fellow in Clinical Science at The University of Cambridge and faculty at the Africa Health Research Institute in Durban, South Africa. Gupta graduated with a medical degree from Cambridge University in 1997. Lancet Infectious Diseases;2009;9(7):409-17. Point of Care Nucleic Acid Testing for SARS-CoV-2 in Hospitalized Patients: A Clinical Validation Trial and Implementation Study. Gupta's group did not claim that he was the first to develop the B.1.1.7 mutation or that it spread from him to other people. Gupta graduated with a medical degree from Cambridge University in 1997. Ravindra "Ravi" Kumar Gupta é um professor de microbiologia do Instituto de Imunologia Terapêutica e Doenças Infecciosas da Universidade de Cambridge. Indian origin HIV biologist Professor Ravindra Gupta is one of the 100 influential personalities listed by the Times magazine for 2020. He is the professor of Clinical Microbiology and Wellcome Trust Senior Fellow in Clinical Science at The University of Cambridge and faculty at the Africa Health Research Institute in Durban, South Africa. Below are key publications from the Gupta lab. ; 2017 Apr 15;64(8):1006-1016, Petra Mlcochova, Katherine A Sutherland, Sarah A Watters, Cosetta Bertoli, Rob AM de Bruin, Jan Rehwinkel, Stuart J Neil, Gina M Lenzi, Baek Kim, Asim Khwaja, Matthew C Gage, Christiana Georgiou, Alexandra Chittka, Simon Yona, Mahdad Noursadeghi, Greg J Towers, Gupta RK. Indian-origin Biologist Named in Times 100 Most Influential List for HIV Research, Malaika Arora Raises The Hotness Quotient With Her Ravishing Looks, See Her Pics, Kamya Panjabi Stuns In Bikini, See The Actress Flaunting Her Body In These Pics. Professor Ravindra "Ravi" Kumar Gupta is a professor of clinical microbiology at the Cambridge Institute of Therapeutic Immunology and Infectious Disease at the University of Cambridge.He is also a member of the faculty of the Africa Health Research Institute in Durban, South Africa. Ravindra Gupta led a team of doctors that enabled a second person to experience sustained remission from AIDS after ceasing treatment, according to a study published in Nature. While the convalescent plasma didn’t seem to harm the patient, it offered no clear benefit, said senior author Ravindra Gupta, a professor of clinical microbiology at the Cambridge Institute of Therapeutic Immunology and Infectious Disease. Our work focuses on two areas: Gupta graduated with a medical degree from Cambridge University in 1997. How you can support Cambridge’s COVID-19 research Ravindra Prof. Gupta, BMBCh: University of Cambridge & Cambridge University Hospitals NHS Foundation Trust: More Information. Cookie information is stored in your browser and performs functions such as recognising you when you return to our website and helping our team to understand which sections of the website you find most interesting and useful. Addenbrooke's Hospital - Division of Virology. “At the moment the only way to treat HIV is with medications that suppress the virus, which people need to take for their entire lives, posing a particular challenge in developing countries,” said the study’s lead author, Professor Ravindra Gupta (UCL Infection & Immunity, UCLH and University of Cambridge). This means that every time you visit this website you will need to enable or disable cookies again. Strictly Necessary Cookie should be enabled at all times so that we can save your preferences for cookie settings. He established his research group at UCL in 2011 working on genetics and biology of HIV resistance and reservoirs and as promoted to full professor in 2016. Ravindra Gupta The case report, carried out by researchers at UCL and Imperial College London, together with teams at the University of Cambridge and the University of Oxford, comes ten years after the first such case, known as the ‘Berlin Patient.’ The case history of a U.K. man in his 70s shows how selective “pressures” bring about viral mutations "He has championed me and empowered me to become an ambassador of hope to millions of people living with HIV around the world," Castillejo says about the professor. Links. His recent work is aimed at cell cycle dependent changes in macrophage biological activity and viral permissivity. Gupta RK, Abdul-Jawad S, McCoy LE, Mok HP, Peppa D, Salgado M, Martinez-Salasc F, Monit C, Innes A, Muir L, Waters L, Frater AJ, Lever AML, Edwards SG, Gabriel IH, Olavarria E, HIV-1 remission following CCR5Δ32/Δ32 haematopoietic stem-cell transplantation.Nature 2019; Apr;568(7751):244-248 . In recognition of his work, last year the University of Cambridge appointed him professor of clinical microbiology at the Cambridge Institute of Therapeutic Immunology and Infectious Disease. Gupta RK, Sultan BJ, Hill A, Davis DHJ, Gregson J, Sawyer W, Hamers RL, Ndembi N, Pillay D, Jordan MR & Bertagnolio S. Global trends in antiretroviral resistance in untreated HIV-1 infected individuals following ART roll-out in resource-limited settings: a global collaborative study and meta-regression analysis. The patient was being treated for a lymphoma that had relapsed and had been given rituximab, a drug that depletes antibody-producing B cells. HIV-1 remission following CCR5Δ32/Δ32 haematopoietic stem-cell transplantation, DNA damage induced by topoisomerase inhibitors activates SAMHD1 and blocks HIV-1 infection of macrophages, HIV-1 drug resistance prior to initiation or re-initiation of first-line antiretroviral therapy in low- and middle-income countries – a meta regression analysis, Virological Outcomes of second– line protease inhibitor based treatment for HIV– 1 in a high prevalence rural South African setting – a competing risk prospective cohort analysis, A G1‐like state allows HIV‐1 to bypass SAMHD1 restriction in macrophages, Diffuse white matter signal abnormalities on MRI are associated with HIV-1 viral escape in the central nervous system among patients with neurological symptoms, Occult drug resistance to thymidine analogues and multidrug resistant HIV-1 following failure of first line tenofovir-based antiretroviral regimens in sub Saharan Africa: a retrospective multi-centre cohort study, Global epidemiology of drug resistance following failure of WHO recommended first line regimens for adult HIV-1 infection – a multi-centre retrospective cohort study, Proof-of-principle for immune control of global HIV-1 reactivation in vivo, Global trends in antiretroviral resistance in untreated HIV-1 infected individuals following ART roll-out in resource-limited settings: a global collaborative study and meta-regression analysis, Simian Immunodeficiency Virus envelope glycoprotein counteracts tetherin/BST-2/CD317 by intracellular sequestration, Mutation of a single residue renders human tetherin resistant to HIV-1 Vpu-mediated depletion, monitoring and resistance to first-line highly active antiretroviral therapy in adults infected with HIV-1 treated under WHO guidelines: a systematic review and meta-analysis. The Lancet;2012. Evidence for HIV-1 Cure in the ‘London Patient’. File image of Ravindra Gupta. The group is also involved in testing novel materials for anti SARS-CoV-2 activity for PPE as part of the 3D MFM collaboration. In June, Ravindra Gupta, a virologist at the University of Cambridge, heard about a cancer patient who had come into a local hospital the month before … The New and Emerging Respiratory Virus Threats Advisory Group (NERVTAG) advises the government on the threat posed by new and emerging respiratory viruses. Lead researcher Prof Ravindra Kumar Gupta, from the University of Cambridge, told BBC News: "This represents HIV cure with almost certainty. Ravi Gupta is a co-opted member of NERVTAG. Assistant Professor of Anesthesiology Edit My Profile Become a Media Expert. TLR4-Mediated Pathway Triggers Interferon-Independent G0 Arrest and Antiviral SAMHD1 Activity in Macrophages. Lancet Infectious Diseases; 2018 Mar;18(3):346-355, Collier DA, Iwuji C, Derache A, de Oliveira T, Okesola N, Calmy A, Dabis F, Pillay D, Gupta RK for the ANRS 12249 TasP Study Group. Combined point of care nucleic acid and antibody testing for SARS-CoV-2 following emergence of D614G Spike Variant. I n 2020 he was named as one of the 100 Most influential people by TIME. A G1‐like state allows HIV‐1 to bypass SAMHD1 restriction in macrophages. Cited by. Ravindra K Gupta Background: Lack of viral load monitoring of ART is known to be associated with slower switch from a failing regimen and thereby higher prevalence of MDR HIV-1. Research in the Gupta lab focusses on host-pathogen and drug-pathogen interactions to inform HIV treatment and curative strategies. Indian origin HIV biologist Professor Ravindra Gupta is one of the 100 influential personalities listed by the Times magazine for 2020. Bio Publications Disclosures. Gupta RK, Dimitra Peppa, Alison L Hill Cristina Gálvez Maria Salgado5Matthew Pace, Laura E McCoySarah A Griffith, John Thornhill, Aljawharah Alrubayyi, Laura EP Huyveneers, Eleni Nastouli, Paul Grant, Simon G Edwards S , Andrew J Innes, John Frater, Monique Nijhuis, Anne Marie J, Wensing Prof Martinez-Picado J, Eduardo Olavarria. Sort. View the profiles of people named Ravindra Gupta. Reduced efficacy of HIV-1 integrase inhibitors in patients with drug resistance mutations in reverse transcriptase. (photo taken from African Health Research Institute website). In press, The Lancet HIV; 2020, MlcochovaP, Winstone H, Zuliani-Alvarez L, Gupta RK.TLR4-Mediated Pathway Triggers Interferon-Independent G0 Arrest and Antiviral SAMHD1 Activity in Macrophages. Cell Reports Medicine; 2020 Sep 1:100099. doi:10.1016/j.xcrm.2020.100099, Datir RP, Kemp S, El Bouzidi K, Mlcochova P, Goldstein RA, Breuer J, Towers GJ, Jolly C, Quinones-Mateu ME, Dakum PS, Ndembi N, Gupta RK. Find out why Ravindra Gupta is one of the 100 most influential people of 2020. Myra Hosmillo. Mutation of a single residue renders human tetherin resistant to HIV-1 Vpu-mediated depletion. Please enable Strictly Necessary Cookies first so that we can save your preferences! Known as the London Patient, Castillejo is the second person ever to be functionally cured of HIV. Virological failure, HIV-1 drug resistance and early mortality in adults admitted to hospital in Malawi: a nested observational cohort study. Articles Cited by Co-authors. Honorary staff. Oct 6;380(9849):1250-8. His research identified key mutations in … Go to Top of Page Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information. Articles Cited by Co-authors. Hier sollte eine Beschreibung angezeigt werden, diese Seite lässt dies jedoch nicht zu. Professor Ravindra "Ravi" Kumar Gupta is a professor of clinical microbiology at the Cambridge Institute of Therapeutic Immunology and Infectious Disease at the University of Cambridge.He is also a member of the faculty of the Africa Health Research Institute in Durban, South Africa. Ravindra A Gupta. Gupta was included in Time magazine 's 100 Most Influential People in 2020. Cell Reports; 2020; 30 (12), 3972-3980. Castillejo recalls his first meeting with Gupta and says he was 'pleasantly surprised' on seeing him. Diffuse white matter signal abnormalities on MRI are associated with HIV-1 viral escape in the central nervous system among patients with neurological symptoms. The Gupta lab has teams in both London and at the Africa Health Research Institute in Durban South Africa. This understanding is relevant to both anatomical compartments where HIV virus replication occurs in macrophages, as well as design of strategies to cure HIV. Professor Ravindra "Ravi" Kumar Gupta is a professor of clinical microbiology at the Cambridge Institute of Therapeutic Immunology and Infectious Disease at the University of Cambridge.He is also a member of the faculty of the Africa Health Research Institute in Durban, South Africa. Occult drug resistance to thymidine analogues and multidrug resistant HIV-1 following failure of first line tenofovir-based antiretroviral regimens in sub Saharan Africa: a retrospective multi-centre cohort study.

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